Historical Constraints on Vertebrate Genome Evolution
نویسندگان
چکیده
منابع مشابه
Historical Constraints on Vertebrate Genome Evolution
Recent analyses indicated that genes with larger effect of knockout or mutation and with larger probability to revert to single copy after whole genome duplication are expressed earlier in development. Here, we further investigate whether tissue specificity of gene expression is constrained by the age of origin of the corresponding genes. We use 38 metazoan genomes and a comparative genomic app...
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Constraints in embryonic development are thought to bias the direction of evolution by making some changes less likely, and others more likely, depending on their consequences on ontogeny. Here, we characterize the constraints acting on genome evolution in vertebrates. We used gene expression data from two vertebrates: zebrafish, using a microarray experiment spanning 14 stages of development, ...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2009
ISSN: 1759-6653
DOI: 10.1093/gbe/evp052